Aim

The aim of this collaborative study with the University of Bradford is to investigate a) whether an increase of thiols in melanoma cells by MSC-derived exosomes is triggered by an increase in GSH via up-regulation of NRF2, b) whether these cells are viable over time as tumourigenesis is driven by high levels of oxidative stress, c) whether they are now vulnerable to selective apoptosis inducers like resveratrol or inhibitors of survival pathways involving NFkB and PI3K/Akt or NOX inhibitors.

Research question

Can a combined treatment with human cord blood-derived stem cell (CBSC) exosomes and apoptosis inducers / survival factor inhibitors be used to selectively kill melanoma cells?

For further information about the project and how to apply please contact Dr Adi Baumgartner (a.baumgartner@yorksj.ac.uk)